CA4

Across TCGA pan-cancer cohorts, CA4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CA4 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CA4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CA4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where CA4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.273	0.546	<.001	60	view →
LUAD	OS	Quartile	III,IV	0.362	0.785	.006	28	view →
HNSC	OS	Tertile	IV	0.965	0.618	.003	13	view →
CCRCC	OS	Median	IV	1.000	0.451	.016	13	view →
LSCC	DFS	Quartile	All	0.523	1.000	.013	7	view →
GBM	DFS	Quartile	All	0.876	0.641	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CA4–PDAC (OS)

Open the PDAC breakdown →