CA4

Across TCGA pan-cancer cohorts, CA4 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CA4’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CA4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CA4 is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, COAD, and LSCC are the cancer types where CA4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CA4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	II,III,IV	−1.936	<.001	12	view →
COAD	Female	III,IV	−1.822	<.001	12	view →
LSCC	Male	II,III,IV	−2.700	<.001	9	view →
LUAD	Female	All	−2.459	<.001	9	view →
HNSC	Male	IV	−0.655	<.001	8	view →
PDAC	Female	All	−2.006	<.001	7	view →
OV	All	All	−2.018	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CA4–CCRCC

Open the CCRCC breakdown →