CA4

Across TCGA cell cohorts, CA4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CA4-associated genes across cancer lineages are SLC36A3, HBD, and OR5K1. Each is linked with CA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CA4-to-partner and partner-to-CA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC36A3 grouped by CA4-low versus CA4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA4→partner) and Y-score (partner→CA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC36A3 →	+0.017	+4.169	<.001	.001	3	1
LUNG_SCLC	HBD →	+0.120	+3.765	<.001	.006	3	1
LUNG_SCLC	OR5K1 →	+0.050	+4.624	<.001	<.001	3	1
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	1
LUNG_NSCLC_LUAD	ACOD1 →	+0.006	+5.228	.005	.005	3	1
LUNG_NSCLC_LUAD	OR1E3 →	+0.023	+6.266	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SLC36A3 by CA4 expression — LUNG_SCLC

Explore this box plot interactively →