CA3

Across TCGA pan-cancer cohorts, CA3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CA3 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CA3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CA3 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, GBM, and PDAC are the cancer types where CA3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	0.704	0.971	.011	14	view →
GBM	OS	Median	All	0.264	0.499	.011	13	view →
PDAC	OS	Median	II,III,IV	0.684	0.968	.001	11	view →
LSCC	DFS	Median	II,III,IV	1.000	0.419	.008	7	view →
HNSC	OS	Median	II,III,IV	0.952	1.000	.016	6	view →
LUAD	DFS	Quartile	III,IV	0.154	0.993	.010	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CA3–CCRCC (OS)

Open the CCRCC breakdown →