CA3

Across TCGA cell cohorts, CA3 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CA3-associated genes across cancer lineages are CNPY1, FEZF2, and MOS. Each is linked with CA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CA3-to-partner and partner-to-CA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNPY1 grouped by CA3-low versus CA3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA3→partner) and Y-score (partner→CA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CNPY1 →	+0.423	+5.189	<.001	<.001	3	1
LUNG_NSCLC_LUAD	FEZF2 →	+0.021	+5.189	<.001	<.001	3	1
LUNG_NSCLC_LUAD	MOS →	+0.144	+5.189	<.001	<.001	3	1
LUNG_NSCLC_LUAD	AQP12A →	+0.065	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	KCNK18 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	VWC2 →	+0.063	+5.189	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CNPY1 by CA3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →