CA2

Across TCGA pan-cancer cohorts, CA2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CA2 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CA2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CA2 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

LSCC, PDAC, and GBM are the cancer types where CA2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.734	0.998	.004	22	view →
PDAC	DFS	Tertile	All	0.194	0.393	.004	20	view →
GBM	OS	Median	All	0.964	0.745	<.001	15	view →
CCRCC	OS	Median	III,IV	0.202	0.985	.007	10	view →
LUAD	OS	Quartile	III,IV	0.840	0.273	.015	3	view →
HNSC	DFS	Median	IV	1.000	0.413	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CA2–LSCC (DFS)

Open the LSCC breakdown →