CA2

Across TCGA patient cohorts, CA2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,251 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CA2-associated genes across cancer lineages are LONP2, RUSF1, and KPNB1. Each is linked with CA2 in more than 4 cancer types. Because this analysis shows association rather than direction, both CA2-to-partner and partner-to-CA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CA2 versus LONP2 in BRCA, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA2→partner) and Y-score (partner→CA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LONP2 →	+0.643	+0.405	<.001	<.001	3	5
LUAD	RUSF1 →	+0.488	+0.415	<.001	<.001	3	5
LSCC	KPNB1 →	-0.364	-0.190	.002	.009	3	4
HNSC	DOHH →	-1.016	-0.331	<.001	<.001	3	4
OV	TXNDC11 →	+0.361	+0.306	<.001	<.001	3	4
UCEC	EIF1 →	-0.475	-0.416	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,251 associations by consensus.

CA2 vs LONP2 — BRCA

Explore this scatter interactively →