CA2

Across TCGA patient cohorts, CA2 mutation is significantly associated with the RNA expression of many other genes, with 1,039 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CA2-associated genes across cancer lineages are ZNHIT3, NAE1, and TYW3. Each is linked with CA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CA2-to-partner and partner-to-CA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNHIT3 grouped by CA2-low versus CA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA2→partner) and Y-score (partner→CA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNHIT3 →	+0.435	+3.928	.008	<.001	3	2
UCEC	NAE1 →	+0.531	+3.218	.006	.009	3	2
UCEC	TYW3 →	+0.582	+3.213	<.001	.009	3	2
UCEC	MAIP1 →	+0.521	+2.818	.007	.001	3	2
UCEC	ORC5 →	+0.519	+2.807	<.001	.003	3	2
UCEC	LRR1 →	+0.570	+2.807	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,039 associations by consensus.

ZNHIT3 by CA2 expression — UCEC

Explore this box plot interactively →