CA2

Across TCGA patient cohorts, CA2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CA2-associated genes across cancer lineages are STAT3_pY705, VHL, and Caspase-8. Each is linked with CA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CA2-to-partner and partner-to-CA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by CA2-low versus CA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA2→partner) and Y-score (partner→CA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.458	-3.169	<.001	.018	3	1
UCEC	VHL →	-1.279	-3.321	<.001	.010	3	1
UCEC	Caspase-8 →	-0.359	-3.432	.003	.005	3	1
UCEC	CD49b →	-0.407	-3.150	.003	.019	3	1
UCEC	Cyclin-B1 →	+0.666	+2.459	.014	.020	3	1
UCEC	Di-Ras3 →	-0.212	-2.986	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

STAT3_pY705 by CA2 expression — UCEC

Explore this box plot interactively →