CA2

Across TCGA cell cohorts, CA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,277 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CA2-associated GO terms across cancer lineages are Proton transmembrane transport, Aerobic electron transport chain, and ATP synthesis coupled electron transport. Each is linked with CA2 in more than 6 cancer types. Because this analysis shows association rather than direction, both CA2-to-partner and partner-to-CA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proton transmembrane transport grouped by CA2-low versus CA2-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CA2→partner) and Y-score (partner→CA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Proton transmembrane transport →	+0.076	+3.458	<.001	<.001	3	7
BLOOD_Myeloma	Aerobic electron transport chain →	+0.102	+2.533	.002	.006	3	7
BLOOD_Lymphoma	ATP synthesis coupled electron transport →	+0.087	+1.998	<.001	<.001	3	7
BLOOD_Lymphoma	Mitochondrial ATP synthesis coupled electron transport →	+0.087	+1.998	<.001	<.001	3	7
BLOOD_Lymphoma	Mitochondrial electron transport, NADH to ubiquinone →	+0.087	+1.933	<.001	<.001	3	7
LARGE_INTESTINE	Mitochondrial calcium ion transmembrane transport →	+0.086	+1.245	.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,277 associations by consensus.

Proton transmembrane transport by CA2 expression — BLOOD_Leukemia

Explore this box plot interactively →