CA14

Across TCGA pan-cancer cohorts, CA14 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CA14 data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher CA14 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CA14 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, ESCA, and UCEC are the cancer types where CA14 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.120	0.578	.019	12	view →
ESCA	OS	Median	All	0.022	0.701	<.001	12	view →
UCEC	DFS	Median	All	1.000	0.628	.017	12	view →
SKCM	OS	Median	III,IV	0.230	0.721	.004	12	view →
LIHC	OS	Median	All	0.152	0.688	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CA14–BRCA (OS)

Open the BRCA breakdown →