CA14

Across TCGA patient cohorts, CA14 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CA14-associated genes across cancer lineages are 4E-BP1, p62 Lck ligand, and 14-3-3_beta. Each is linked with CA14 in more than 2 cancer types. Because this analysis shows association rather than direction, both CA14-to-partner and partner-to-CA14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CA14-low versus CA14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA14→partner) and Y-score (partner→CA14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.298	+2.199	.007	.033	3	3
UCEC	p62 Lck ligand →	+0.301	+3.169	.025	.018	3	2
UCEC	14-3-3_beta →	-0.107	-3.295	.009	.009	3	1
UCEC	EGFR_pY1068 →	-0.269	-3.584	.009	.002	3	1
UCEC	A-Raf_pS299 →	-0.109	-2.321	.027	.034	3	1
UCEC	ERK2 →	+0.215	+3.321	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

4E-BP1 by CA14 expression — UCEC

Explore this box plot interactively →