CA12

Across TCGA pan-cancer cohorts, CA12 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CA12 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CA12 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CA12 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where CA12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.394	0.836	.001	26	view →
PDAC	DFS	Tertile	II,III,IV	0.666	0.892	.004	10	view →
LUAD	DFS	Median	III,IV	0.614	0.867	.020	7	view →
HNSC	DFS	Tertile	II,III,IV	0.989	0.897	.048	1	view →
LSCC	DFS	Median	II,III,IV	0.988	0.844	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CA12–CCRCC (DFS)

Open the CCRCC breakdown →