CA10

Across TCGA patient cohorts, CA10 mutation is significantly associated with the RNA expression of many other genes, with 1,301 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CA10-associated genes across cancer lineages are SEC13, ISL2, and TIMM44. Each is linked with CA10 in more than 2 cancer types. Because this analysis shows association rather than direction, both CA10-to-partner and partner-to-CA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC13 grouped by CA10-low versus CA10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA10→partner) and Y-score (partner→CA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC13 →	+0.354	+2.617	.001	.005	3	3
UCEC	ISL2 →	+0.564	+2.850	<.001	.001	3	3
UCEC	TIMM44 →	+0.348	+1.839	.001	.002	3	3
UCEC	UBE2S →	+0.635	+3.700	.002	.001	3	3
UCEC	CMC1 →	+0.299	+2.343	.004	.003	3	3
SKCM	TLE6 →	+0.504	+1.786	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,301 associations by consensus.

SEC13 by CA10 expression — UCEC

Explore this box plot interactively →