CA1

Across TCGA patient cohorts, CA1 mutation is significantly associated with the RNA expression of many other genes, with 1,585 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CA1-associated genes across cancer lineages are MIR541, C19orf81, and ZC3H18. Each is linked with CA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CA1-to-partner and partner-to-CA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR541 grouped by CA1-low versus CA1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA1→partner) and Y-score (partner→CA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR541 →	+0.127	+3.147	<.001	.005	3	3
UCEC	C19orf81 →	+0.814	+2.815	.003	.001	3	2
UCEC	ZC3H18 →	+0.491	+3.753	<.001	<.001	3	2
UCEC	CCNF →	+0.525	+2.329	.007	.003	3	2
SKCM	CIAO2B →	+0.435	+3.785	<.001	<.001	3	2
UCEC	CDT1 →	+0.839	+2.769	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,585 associations by consensus.

MIR541 by CA1 expression — SKCM

Explore this box plot interactively →