CA1

Across TCGA patient cohorts, CA1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CA1-associated genes across cancer lineages are Smad4, FASN, and JNK2. Each is linked with CA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CA1-to-partner and partner-to-CA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad4 grouped by CA1-low versus CA1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA1→partner) and Y-score (partner→CA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Smad4 →	+0.151	+2.182	.003	.033	3	2
UCEC	FASN →	+0.368	+2.807	.012	.003	3	2
UCEC	JNK2 →	+0.193	+2.196	.009	.032	3	2
UCEC	MEK1 →	+0.445	+2.662	.001	<.001	3	2
UCEC	ATM →	-0.540	-1.861	.001	.049	3	2
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.780	+3.169	.002	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Smad4 by CA1 expression — SKCM

Explore this box plot interactively →