C9orf78

Across TCGA pan-cancer cohorts, C9orf78 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated C9orf78 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher C9orf78 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C9orf78 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where C9orf78 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.789	0.442	.001	45	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
HNSC	DFS	Quartile	IV	0.513	0.890	.006	7	view →
COAD	DFS	Quartile	III,IV	0.778	1.000	.036	6	view →
LUAD	OS	Quartile	All	0.682	1.000	.012	5	view →
GBM	OS	Tertile	All	0.493	0.271	.014	3	view →
LSCC	DFS	Quartile	II,III,IV	0.933	0.626	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

C9orf78–CCRCC (DFS)

Open the CCRCC breakdown →