C9orf78

Across TCGA patient cohorts, C9orf78 mutation is significantly associated with the RNA expression of many other genes, with 622 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf78-associated genes across cancer lineages are RNA5SP147, ATF4P2, and RN7SKP232. Each is linked with C9orf78 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf78-to-partner and partner-to-C9orf78 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP147 grouped by C9orf78-low versus C9orf78-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf78→partner) and Y-score (partner→C9orf78) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP147 →	+0.309	+6.324	<.001	.001	3	2
COAD	ATF4P2 →	+0.062	+3.993	<.001	.005	3	2
UCEC	RN7SKP232 →	+0.155	+3.133	.001	.002	3	2
CESC	CICP10 →	+0.313	+4.760	<.001	.003	3	2
UCEC	SNX3P1Y →	+0.149	+5.156	<.001	.001	3	2
UCEC	MIR6081 →	+0.353	+2.769	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 622 associations by consensus.

RNA5SP147 by C9orf78 expression — BRCA

Explore this box plot interactively →