C9orf78

Across TCGA patient cohorts, C9orf78 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf78-associated genes across cancer lineages are GSK-3a-b_pS21_S9, N-Cadherin, and VEGFR2. Each is linked with C9orf78 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf78-to-partner and partner-to-C9orf78 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by C9orf78-low versus C9orf78-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf78→partner) and Y-score (partner→C9orf78) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.600	+3.000	.015	.037	3	1
UCEC	N-Cadherin →	-0.277	-3.000	.023	.037	3	1
UCEC	VEGFR2 →	+0.558	+2.817	.001	.036	3	1
UCEC	p62 Lck ligand →	+0.431	+3.000	.022	.037	1	1
UCEC	PRAS40_pT246 →	+0.266	+3.013	.007	.019	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GSK-3a-b_pS21_S9 by C9orf78 expression — UCEC

Explore this box plot interactively →