C9orf78

Across TCGA cell cohorts, C9orf78 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C9orf78-associated genes across cancer lineages are C9, OLFM3, and C20orf85. Each is linked with C9orf78 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf78-to-partner and partner-to-C9orf78 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9 grouped by C9orf78-low versus C9orf78-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf78→partner) and Y-score (partner→C9orf78) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C9 →	+1.030	+4.038	<.001	.001	3	1
BLOOD_Leukemia	OLFM3 →	+0.812	+3.474	<.001	.007	3	1
BLOOD_Leukemia	C20orf85 →	+0.030	+4.554	<.001	<.001	3	1
BLOOD_Leukemia	IL22 →	+0.021	+4.247	<.001	.004	3	1
BLOOD_Leukemia	IL36A →	+0.824	+3.536	<.001	.008	3	1
BLOOD_Leukemia	BTBD16 →	+0.116	+3.281	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

C9 by C9orf78 expression — BLOOD_Leukemia

Explore this box plot interactively →