C9orf72

Across TCGA pan-cancer cohorts, C9orf72 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated C9orf72 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C9orf72 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C9orf72 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where C9orf72 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.861	1.000	.001	27	view →
PDAC	OS	Tertile	III,IV	0.536	1.000	.038	6	view →
CCRCC	OS	Tertile	II,III,IV	0.466	1.000	.024	6	view →
LUAD	DFS	Quartile	III,IV	1.000	0.440	.040	2	view →
GBM	DFS	Quartile	All	0.904	0.667	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

C9orf72–HNSC (DFS)

Open the HNSC breakdown →