C9orf72

Across TCGA patient cohorts, C9orf72 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,278 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible C9orf72-associated proteins across cancer lineages are SMCR8, PLAA, and PSIP1. Each is linked with C9orf72 in more than 6 cancer types. Because this analysis shows association rather than direction, both C9orf72-to-partner and partner-to-C9orf72 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C9orf72 versus SMCR8 in HNSC, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf72→partner) and Y-score (partner→C9orf72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMCR8 →	+0.380	+0.803	<.001	<.001	3	7
LSCC	PLAA →	+0.448	+0.767	<.001	<.001	3	6
BRCA	PSIP1 →	+0.431	+0.498	.003	.002	3	5
BRCA	AP1G1 →	-0.262	-0.524	<.001	.002	3	4
OV	LRRC59 →	-0.425	-0.728	.002	.001	3	4
HNSC	S100A16 →	-0.629	-0.871	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,278 associations by consensus.

C9orf72 vs SMCR8 — HNSC

Explore this scatter interactively →