C9orf72

Across TCGA patient cohorts, C9orf72 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf72-associated genes across cancer lineages are ATM, Claudin-7, and Di-Ras3. Each is linked with C9orf72 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf72-to-partner and partner-to-C9orf72 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by C9orf72-low versus C9orf72-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf72→partner) and Y-score (partner→C9orf72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.514	-2.415	.001	.003	3	2
UCEC	Claudin-7 →	-0.386	-2.321	.030	.034	3	2
UCEC	Di-Ras3 →	-0.140	-2.000	.007	.003	3	2
UCEC	EGFR_pY1068 →	-0.209	-2.000	.018	.029	3	1
UCEC	A-Raf_pS299 →	-0.101	-2.000	.016	.030	3	1
UCEC	JNK2 →	+0.181	+1.362	.010	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ATM by C9orf72 expression — UCEC

Explore this box plot interactively →