C9orf72

Across TCGA cell cohorts, C9orf72 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,756 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible C9orf72-associated GO terms across cancer lineages are Positive regulation of type B pancreatic cell development, Regulation of microtubule polymerization or depolymerization, and Positive regulation of monoatomic ion transport. Each is linked with C9orf72 in more than 10 cancer types. Because this analysis shows association rather than direction, both C9orf72-to-partner and partner-to-C9orf72 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of type B pancreatic cell development grouped by C9orf72-low versus C9orf72-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf72→partner) and Y-score (partner→C9orf72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Positive regulation of type B pancreatic cell development →	-0.184	-1.190	<.001	<.001	3	11
LUNG_SCLC	Regulation of microtubule polymerization or depolymerization →	+0.126	+1.433	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Positive regulation of monoatomic ion transport →	-0.107	-1.698	.001	.002	3	9
SOFT_TISSUE	Regulation of body fluid levels →	-0.074	-0.918	.002	<.001	3	9
LUNG_NSCLC_LUSC	Protein modification by small protein removal →	+0.067	+1.675	.001	.007	3	9
SOFT_TISSUE	Extracellular matrix organization →	-0.161	-0.979	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,756 associations by consensus.

Positive regulation of type B pancreatic cell development by C9orf72 expression — CNS

Explore this box plot interactively →