C9orf64

Across TCGA patient cohorts, C9orf64 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf64-associated genes across cancer lineages are PI3K-p85, A-Raf_pS299, and ERK2. Each is linked with C9orf64 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf64-to-partner and partner-to-C9orf64 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p85 grouped by C9orf64-low versus C9orf64-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf64→partner) and Y-score (partner→C9orf64) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PI3K-p85 →	+0.230	+3.009	.023	.019	3	2
UCEC	A-Raf_pS299 →	-0.123	-3.000	.032	.036	3	1
UCEC	ERK2 →	+0.291	+2.459	.001	.020	3	1
UCEC	GAPDH →	+0.532	+2.459	.040	.020	3	1
UCEC	MSH2 →	-0.368	-3.160	<.001	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.260	+2.472	.009	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PI3K-p85 by C9orf64 expression — UCEC

Explore this box plot interactively →