C9orf50

Across TCGA pan-cancer cohorts, C9orf50 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C9orf50 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher C9orf50 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C9orf50 expression acts as an unfavorable survival marker.

ESCA, HNSC, and SKCM are the cancer types where C9orf50 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.164	0.702	.001	33	view →
HNSC	OS	Median	All	0.099	0.768	<.001	12	view →
SKCM	DFS	Median	II,III,IV	0.088	0.691	.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

C9orf50–ESCA (OS)

Open the ESCA breakdown →