Across TCGA patient cohorts, C9orf47 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf47-associated genes across cancer lineages are 4E-BP1, A-Raf_pS299, and ERK2. Each is linked with C9orf47 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf47-to-partner and partner-to-C9orf47 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf47→partner) and Y-score (partner→C9orf47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.332	+3.614	.001	.001	3	2
UCEC	A-Raf_pS299 →	-0.145	-2.115	.002	.017	3	1
UCEC	ERK2 →	+0.176	+2.459	.019	.019	3	1
UCEC	Heregulin →	-0.111	-2.000	.021	.010	3	1
UCEC	IGFBP2 →	-0.586	-2.459	.021	.019	3	1
UCEC	JNK2 →	+0.227	+2.469	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

C9orf47 survival (RNA) · tumor vs normal (RNA) · all C9orf47 data types