C9orf40

Across TCGA pan-cancer cohorts, C9orf40 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated C9orf40 data layer compared with 19 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher C9orf40 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C9orf40 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

PDAC, LUAD, and GBM are the cancer types where C9orf40 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.302	0.569	.006	36	view →
LUAD	DFS	Median	All	0.801	0.973	<.001	30	view →
GBM	DFS	Median	All	0.272	0.468	<.001	9	view →
CCRCC	DFS	Quartile	All	0.908	0.646	.029	2	view →
LSCC	DFS	Tertile	All	0.884	1.000	.017	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

C9orf40–PDAC (DFS)

Open the PDAC breakdown →