C9orf40

Across TCGA patient cohorts, C9orf40 mutation is significantly associated with the RNA expression of many other genes, with 611 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf40-associated genes across cancer lineages are RNA5SP200, OR8J1, and COX6CP4. Each is linked with C9orf40 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf40-to-partner and partner-to-C9orf40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP200 grouped by C9orf40-low versus C9orf40-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf40→partner) and Y-score (partner→C9orf40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP200 →	+0.363	+7.640	<.001	.009	3	2
COAD	OR8J1 →	+0.074	+7.741	<.001	.009	3	2
SKCM	COX6CP4 →	+0.289	+6.797	<.001	<.001	3	1
UCEC	RNA5SP414 →	+0.548	+3.032	.001	<.001	3	1
UCEC	MIR7976 →	+0.395	+2.775	.002	.002	3	1
UCEC	FRG1HP →	+0.627	+3.191	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 611 associations by consensus.

RNA5SP200 by C9orf40 expression — BLCA

Explore this box plot interactively →