C9orf40

Across TCGA patient cohorts, C9orf40 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf40-associated genes across cancer lineages are ERK2, SLC1A5, and JNK2. Each is linked with C9orf40 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf40-to-partner and partner-to-C9orf40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by C9orf40-low versus C9orf40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf40→partner) and Y-score (partner→C9orf40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.238	+3.321	.018	.010	3	1
UCEC	SLC1A5 →	-0.503	-2.992	.040	.036	3	1
UCEC	JNK2 →	+0.276	+3.321	.008	.010	1	1
UCEC	MEK1 →	+0.539	+3.321	.004	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ERK2 by C9orf40 expression — UCEC

Explore this box plot interactively →