Across TCGA patient cohorts, C9orf153 mutation is significantly associated with the RNA expression of many other genes, with 1,021 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf153-associated genes across cancer lineages are RNU1-74P, CHEK1, and TAOK2. Each is linked with C9orf153 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf153-to-partner and partner-to-C9orf153 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf153→partner) and Y-score (partner→C9orf153) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU1-74P →	+0.243	+5.292	<.001	.006	3	2
UCEC	CHEK1 →	+0.726	+3.345	.003	.005	3	1
UCEC	TAOK2 →	+0.396	+2.595	.004	.006	3	1
UCEC	TIRAP →	+0.530	+3.483	.004	.002	3	1
UCEC	DHX37 →	+0.549	+2.649	.001	.005	3	1
UCEC	KCTD14 →	+1.302	+3.338	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,021 associations by consensus.

Exploration

C9orf153 survival (RNA) · tumor vs normal (RNA) · all C9orf153 data types