Across TCGA patient cohorts, C9orf152 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf152-associated genes across cancer lineages are p90 RSK, Fibronectin, and ACC1. Each is linked with C9orf152 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf152-to-partner and partner-to-C9orf152 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf152→partner) and Y-score (partner→C9orf152) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.270	+3.335	.007	.005	3	2
UCEC	Fibronectin →	-0.373	-2.990	.030	.036	3	1
UCEC	ACC1 →	+0.569	+2.820	.002	.035	3	1
UCEC	PCNA →	+0.307	+3.169	.006	.019	3	1
UCEC	PDK1_pS241 →	+0.199	+3.000	.026	.036	3	1
UCEC	STAT3_pY705 →	-0.477	-3.159	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

C9orf152 survival (RNA) · tumor vs normal (RNA) · all C9orf152 data types