C9orf139

Across TCGA pan-cancer cohorts, C9orf139 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated C9orf139 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher C9orf139 RNA is associated with better overall survival. In most high-consensus cancer types, elevated C9orf139 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and KIRC are the cancer types where C9orf139 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.428	0.262	<.001	138	view →
HNSC	OS	Median	All	0.732	0.593	<.001	137	view →
KIRC	OS	Median	All	0.516	0.699	<.001	97	view →
PAAD	OS	Median	All	0.528	0.255	<.001	95	view →
CESC	OS	Median	IV	0.669	0.085	<.001	66	view →
UCEC	DFS	Quartile	All	0.708	0.543	<.001	36	view →
OV	DFS	Median	All	0.421	0.339	.006	36	view →
PRAD	DFS	Median	All	0.672	0.898	<.001	22	view →
COAD	OS	Median	All	0.493	0.693	.004	19	view →
KIRP	DFS	Quartile	III,IV	0.098	0.525	.008	15	view →
LUAD	OS	Median	All	0.738	0.633	.007	14	view →
THYM	OS	Median	All	0.741	0.980	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

C9orf139–SKCM (OS)

Open the SKCM breakdown →