Across TCGA patient cohorts, C9orf135 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf135-associated genes across cancer lineages are Cyclin-E2, EGFR_pY1068, and eIF4E. Each is linked with C9orf135 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf135-to-partner and partner-to-C9orf135 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf135→partner) and Y-score (partner→C9orf135) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.171	+2.584	.008	.001	3	2
UCEC	EGFR_pY1068 →	-0.307	-2.584	.001	.001	3	1
UCEC	eIF4E →	+0.172	+2.183	.034	.033	3	1
UCEC	eIF4G →	+0.258	+1.678	.030	.023	3	1
UCEC	A-Raf_pS299 →	-0.150	-2.000	.001	.030	3	1
UCEC	FASN →	+0.459	+1.678	.002	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

C9orf135 survival (RNA) · tumor vs normal (RNA) · all C9orf135 data types