C9orf131

Across TCGA patient cohorts, C9orf131 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf131-associated genes across cancer lineages are Caspase-7-cleavedD198, FASN, and Rab25. Each is linked with C9orf131 in more than 2 cancer types. Because this analysis shows association rather than direction, both C9orf131-to-partner and partner-to-C9orf131 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by C9orf131-low versus C9orf131-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf131→partner) and Y-score (partner→C9orf131) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.761	+2.107	<.001	.002	3	3
LUAD	FASN →	+0.542	+3.169	.020	.019	3	2
UCEC	Rab25 →	-0.237	-1.584	.035	.034	3	2
SKCM	Annexin-1 →	+0.606	+3.000	.001	.034	3	2
UCEC	ACC1 →	+0.269	+1.247	.030	.045	3	2
UCEC	INPP4B →	-0.267	-2.169	.015	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Caspase-7-cleavedD198 by C9orf131 expression — UCEC

Explore this box plot interactively →