C9orf131

Across TCGA cell cohorts, C9orf131 mutation is significantly associated with the RNA expression of many other genes, with 715 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C9orf131-associated genes across cancer lineages are KCNA5, NLRP8, and OR2T29. Each is linked with C9orf131 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf131-to-partner and partner-to-C9orf131 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNA5 grouped by C9orf131-low versus C9orf131-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf131→partner) and Y-score (partner→C9orf131) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KCNA5 →	+0.032	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	NLRP8 →	+0.037	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	OR2T29 →	+0.169	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	ZNF728 →	+0.010	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	PRAMEF5 →	+0.080	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	PRAMEF18 →	+0.112	+4.357	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 715 associations by consensus.

KCNA5 by C9orf131 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →