C9orf116

Across TCGA cell cohorts, C9orf116 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,959 significant associations in total. BONE shows the largest number of these associations.

The most reproducible C9orf116-associated GO terms across cancer lineages are Fatty acid oxidation, Cellular response to forskolin, and RNA splicing, via transesterification reactions with bulged adenosine as nucleophile. Each is linked with C9orf116 in more than 8 cancer types. Because this analysis shows association rather than direction, both C9orf116-to-partner and partner-to-C9orf116 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fatty acid oxidation grouped by C9orf116-low versus C9orf116-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf116→partner) and Y-score (partner→C9orf116) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Fatty acid oxidation →	+0.058	+1.036	.003	.003	3	9
BONE	Cellular response to forskolin →	-0.122	-1.096	<.001	.002	3	8
SKIN	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.054	+0.709	.002	.002	3	7
SKIN	mRNA splicing, via spliceosome →	+0.054	+0.709	.002	.002	3	7
BONE	Muscle organ development →	-0.135	-1.495	<.001	<.001	3	7
LIVER	Fat cell proliferation →	-0.349	-1.347	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,959 associations by consensus.

Fatty acid oxidation by C9orf116 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →