C8orf74

Across TCGA pan-cancer cohorts, C8orf74 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated C8orf74 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher C8orf74 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C8orf74 expression acts as an unfavorable survival marker.

SCLC, LIHC, and BLCA are the cancer types where C8orf74 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.192	0.699	.002	18	view →
LIHC	DFS	Median	All	0.053	0.553	<.001	12	view →
BLCA	DFS	Median	III,IV	0.121	0.548	.005	6	view →
LUAD	OS	Median	All	0.276	0.697	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

C8orf74–SCLC (OS)

Open the SCLC breakdown →