C8orf74

Across TCGA patient cohorts, C8orf74 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,659 significant associations in total. STAD shows the largest number of these associations.

The most reproducible C8orf74-associated GO terms across cancer lineages are Establishment of skin barrier, Mammary gland development, and Cell cycle G1/S phase transition. Each is linked with C8orf74 in more than 11 cancer types. Because this analysis shows association rather than direction, both C8orf74-to-partner and partner-to-C8orf74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of skin barrier grouped by C8orf74-low versus C8orf74-high in PAAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf74→partner) and Y-score (partner→C8orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	Establishment of skin barrier →	+0.083	+0.380	<.001	<.001	3	12
STAD	Mammary gland development →	+0.048	+0.102	<.001	<.001	3	11
STAD	Cell cycle G1/S phase transition →	+0.057	+0.160	<.001	<.001	2	11
STAD	Positive regulation of DNA metabolic process →	+0.063	+0.135	<.001	.001	2	11
STAD	Transcription by RNA polymerase I →	+0.047	+0.095	<.001	<.001	3	10
STAD	Phosphate ion transmembrane transport →	+0.057	+0.138	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,659 associations by consensus.

Establishment of skin barrier by C8orf74 expression — PAAD

Explore this box plot interactively →