C8orf74

Across TCGA patient cohorts, C8orf74 mutation is significantly associated with the RNA expression of many other genes, with 1,110 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C8orf74-associated genes across cancer lineages are TPT1P11, RPSAP37, and RPL35AP34. Each is linked with C8orf74 in more than 1 cancer types. Because this analysis shows association rather than direction, both C8orf74-to-partner and partner-to-C8orf74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPT1P11 grouped by C8orf74-low versus C8orf74-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf74→partner) and Y-score (partner→C8orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TPT1P11 →	+0.059	+3.086	<.001	.004	3	2
SKCM	RPSAP37 →	+0.025	+3.867	<.001	.002	3	2
SKCM	RPL35AP34 →	+0.160	+2.693	.002	.006	3	2
COAD	RPSAP51 →	+0.164	+3.584	<.001	.002	3	2
COAD	RNA5SP459 →	+0.309	+5.831	<.001	<.001	3	2
COAD	SLC20A1P3 →	+0.051	+4.595	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,110 associations by consensus.

TPT1P11 by C8orf74 expression — SKCM

Explore this box plot interactively →