C8orf74

Across TCGA patient cohorts, C8orf74 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C8orf74-associated genes across cancer lineages are GAPDH, PKC-delta_pS664, and Caspase-7-cleavedD198. Each is linked with C8orf74 in more than 2 cancer types. Because this analysis shows association rather than direction, both C8orf74-to-partner and partner-to-C8orf74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by C8orf74-low versus C8orf74-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf74→partner) and Y-score (partner→C8orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.507	+3.000	.042	.036	3	3
UCEC	PKC-delta_pS664 →	-0.120	-2.999	.031	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.713	+2.189	.009	.034	3	2
UCEC	EGFR_pY1068 →	-0.267	-2.321	.022	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.256	-3.169	.001	.018	3	1
UCEC	mTOR →	-0.255	-2.584	<.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

GAPDH by C8orf74 expression — UCEC

Explore this box plot interactively →