C8orf74

Across TCGA cell cohorts, C8orf74 RNA expression is significantly associated with the go_rna of many other GO terms, with 627 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible C8orf74-associated GO terms across cancer lineages are TRAIL-activated apoptotic signaling pathway, Membrane assembly, and Negative regulation of interleukin-6 production. Each is linked with C8orf74 in more than 3 cancer types. Because this analysis shows association rather than direction, both C8orf74-to-partner and partner-to-C8orf74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAIL-activated apoptotic signaling pathway grouped by C8orf74-low versus C8orf74-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf74→partner) and Y-score (partner→C8orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TRAIL-activated apoptotic signaling pathway →	+0.181	+0.080	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	Membrane assembly →	+0.063	+0.069	<.001	<.001	3	3
LARGE_INTESTINE	Negative regulation of interleukin-6 production →	-0.044	-0.111	.006	.007	3	3
UPPER_AERODIGESTIVE_TRACT	Regulation of plasma membrane bounded cell projection assembly →	+0.037	+0.067	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	Regulation of miRNA transcription →	+0.089	+0.083	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	Regulation of nucleocytoplasmic transport →	+0.056	+0.057	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 627 associations by consensus.

TRAIL-activated apoptotic signaling pathway by C8orf74 expression — UPPER_AERODIGESTIVE_TRACT

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