C8orf74

Across TCGA cell cohorts, C8orf74 mutation is significantly associated with the mutation status of many other genes, with 1,401 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C8orf74-associated genes across cancer lineages are PHF3, APP, and ADAMTS3. Each is linked with C8orf74 in more than 2 cancer types. Because this analysis shows association rather than direction, both C8orf74-to-partner and partner-to-C8orf74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF3 grouped by C8orf74-low versus C8orf74-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf74→partner) and Y-score (partner→C8orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PHF3 →	+4.502	+5.066	.007	.007	1	3
SOFT_TISSUE	APP →	+5.502	+5.502	.003	.003	1	3
SOFT_TISSUE	ADAMTS3 →	+4.502	+5.066	.007	.007	1	3
SKIN	IFT52 →	+4.392	+4.392	.009	.009	1	2
SKIN	ASH1L →	+3.169	+4.548	.004	.004	1	2
LUNG_NSCLC_LUAD	SOX11 →	+4.339	+5.303	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,401 associations by consensus.

PHF3 by C8orf74 expression — SOFT_TISSUE

Explore this box plot interactively →