C8orf49

Across TCGA pan-cancer cohorts, C8orf49 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated C8orf49 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher C8orf49 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated C8orf49 expression acts as an unfavorable survival marker, although some lineages such as UVM and THCA show a favorable association.

UVM, ACC, and KICH are the cancer types where C8orf49 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.795	0.429	<.001	110	view →
ACC	OS	Tertile	All	0.613	0.888	<.001	69	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	57	view →
THCA	DFS	Tertile	III,IV	1.000	0.445	.009	45	view →
KIRC	DFS	Tertile	All	0.477	0.658	.003	44	view →
LGG	DFS	Tertile	All	0.634	0.772	.001	41	view →
LUAD	OS	Tertile	III,IV	0.244	0.560	.004	36	view →
KIRP	OS	Tertile	All	0.825	0.946	.001	24	view →
READ	DFS	Tertile	III,IV	0.564	0.220	.024	24	view →
THYM	OS	Tertile	All	0.482	0.943	<.001	18	view →
DLBC	OS	Tertile	IV	0.342	0.930	.045	18	view →
PAAD	DFS	Tertile	All	0.259	0.534	.009	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

C8orf49–UVM (DFS)

Open the UVM breakdown →