C8orf37

Across TCGA pan-cancer cohorts, C8orf37 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated C8orf37 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher C8orf37 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated C8orf37 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where C8orf37 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.928	0.105	.006	34	view →
LSCC	OS	Median	All	0.692	0.880	.012	11	view →
HNSC	OS	Tertile	All	0.819	0.583	.014	7	view →
UCEC	DFS	Tertile	All	0.939	0.765	.021	6	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

C8orf37–CCRCC (DFS)

Open the CCRCC breakdown →