C8orf37

Across TCGA cell cohorts, C8orf37 mutation is significantly associated with the mutation status of many other genes, with 1,980 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C8orf37-associated genes across cancer lineages are EIF3B, PREX1, and SMO. Each is linked with C8orf37 in more than 2 cancer types. Because this analysis shows association rather than direction, both C8orf37-to-partner and partner-to-C8orf37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF3B grouped by C8orf37-low versus C8orf37-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf37→partner) and Y-score (partner→C8orf37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EIF3B →	+3.357	+4.285	.005	.005	1	3
STOMACH	PREX1 →	+4.942	+4.942	.001	.001	1	3
LUNG_NSCLC_LUAD	SMO →	+2.981	+3.266	.009	.009	1	3
LARGE_INTESTINE	ULK2 →	+2.781	+4.504	<.001	<.001	1	2
LARGE_INTESTINE	FCN1 →	+2.459	+3.321	.005	.005	1	2
LUNG_SCLC	CPN2 →	+5.066	+4.502	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,980 associations by consensus.

EIF3B by C8orf37 expression — STOMACH

Explore this box plot interactively →