C8orf33

Across TCGA pan-cancer cohorts, C8orf33 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated C8orf33 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher C8orf33 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C8orf33 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where C8orf33 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.751	0.994	<.001	55	view →
PDAC	OS	Tertile	II,III,IV	0.264	0.488	.004	27	view →
LUAD	OS	Median	II,III,IV	1.000	0.818	.014	8	view →
LSCC	DFS	Median	All	0.460	0.912	.007	5	view →
OV	DFS	Tertile	All	0.834	1.000	.037	4	view →
HNSC	DFS	Median	IV	0.766	0.549	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

C8orf33–CCRCC (OS)

Open the CCRCC breakdown →