C8orf33

Across TCGA patient cohorts, C8orf33 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C8orf33-associated genes across cancer lineages are ERK2, p53, and p62 Lck ligand. Each is linked with C8orf33 in more than 1 cancer types. Because this analysis shows association rather than direction, both C8orf33-to-partner and partner-to-C8orf33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by C8orf33-low versus C8orf33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf33→partner) and Y-score (partner→C8orf33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.285	+3.321	.001	.010	3	1
UCEC	p53 →	-0.369	-3.169	.040	.018	3	1
UCEC	p62 Lck ligand →	+0.331	+3.179	.029	.010	3	1
UCEC	Annexin-1 →	+0.602	+2.827	.014	.035	3	1
UCEC	VHL →	-0.826	-2.584	.009	.011	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ERK2 by C8orf33 expression — UCEC

Explore this box plot interactively →