C8G

Across TCGA pan-cancer cohorts, C8G mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated C8G data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher C8G mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C8G expression acts as an unfavorable survival marker, although some lineages such as CCRCC and OV show a favorable association.

COAD, LUAD, and CCRCC are the cancer types where C8G mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.875	1.000	.015	42	view →
LUAD	OS	Quartile	III,IV	0.372	0.842	.006	19	view →
CCRCC	OS	Median	All	0.951	0.836	.018	14	view →
OV	DFS	Median	All	1.000	0.607	.004	12	view →
LSCC	DFS	Quartile	II,III,IV	0.762	1.000	.006	12	view →
PDAC	OS	Median	All	0.667	0.972	.001	11	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

C8G–COAD (DFS)

Open the COAD breakdown →