C8G

Across TCGA cell cohorts, C8G mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C8G-associated genes across cancer lineages are C20orf173, HHLA1, and CFHR5. Each is linked with C8G in more than 1 cancer types. Because this analysis shows association rather than direction, both C8G-to-partner and partner-to-C8G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf173 grouped by C8G-low versus C8G-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8G→partner) and Y-score (partner→C8G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf173 →	+0.061	+4.133	.006	.003	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	CFHR5 →	+0.003	+4.384	<.001	.006	3	1
BLOOD_Leukemia	NAT2 →	+0.054	+3.551	<.001	.009	3	1
BLOOD_Leukemia	FAM24A →	+0.049	+4.384	<.001	.006	3	1
BLOOD_Leukemia	NXPE2 →	+0.026	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

C20orf173 by C8G expression — BLOOD_Leukemia

Explore this box plot interactively →